Wound Healing

Non-specific wound healing (general concepts); Specific Wounds, Healing by Primary and Secondary Intention.

• 1. Describe the sequence of events in non-specific wound healing, and provide a related time table.


• 2. Define wound contraction.


• 3. Define wound strengthening.


• 4. Compare and contrast abrasion from incision/laceration.


• 5. Describe a wound with epidermal defects.


• 6. Which substances are elaborated, and by which cells (i.e., collagen types, fibronectin, etc)?


• 7. Compare temporary matrix composition vs. definitive matrix composition.


• 8. List the cells, and cell components involved in wound contraction. Provide a time frame of events.


• 9. What is the tensile strength of the wound at time points 1 week, and 3 months?


• 10. Compare the tensile strength of various collagens.


• 11. Describe the time course of healing of a sutured skin wound.


• 12. Compare the processes of primary vs. secondary intention in terms of inflammation, necrosis, cellular proliferation, and scar formation.


• 13. What are the events of healing following bone fracture?


• 14. What are the growth factors involved in wound healing?


• 15. List the local and systemic factors that interfere with wound healing.


• 16. Define pyogenic granuloma and keloid, and describe their morphologic features in histologic sections.


• 17. What is the role of matrix metalloprocesses in wound healing?


• 18. Name a few diseases and factors that interfere with healing.